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Vasopressin, 8-l-arginine-, monoacetate (salt)

Names

[ CAS No. ]:
83968-48-3

[ Name ]:
Vasopressin, 8-l-arginine-, monoacetate (salt)

[Synonym ]:
[Arg8]Vasopressin acetate
8609690
1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (1:1)
MFCD00133939
β-Hypophamine
Antidiuretic hormone
EINECS 204-035-4
[Arg8]-Vasopressin acetate salt
Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-, acetate (1:1) (salt)
1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p ;rolyl-N5-(diaminomethylene)-L-ornithylglycinamide acetate (1:1)
Argipressin acetate
AVP
[8-Arginine]Vasopressin acetate
Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazac ;ycloeicos-4-yl]carbonyl]-L-prolyl-N5-(diaminomethylene)-L-ornithyl-, acetate (1:1) (salt)

Biological Activity

[Description]:

Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively

[In Vitro]

Vasopressin stimulate NKCC2 phosphorylation increase mediated by cAMP-PKA and Ca(2+) signaling in the colon.?The expression and phosphorylation of NKCC2 are increased in the colon by vasopressin stimulation, in association with enhanced activity of the vasopressin/cAMP and Ca(2+) pathways[1].

[References]

1. Xue H , Tang X . Effect of vasopressin on Na+–K+–2Cl? cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon[J]. European Journal of Pharmacology, 2016, 771:241-246.

Chemical & Physical Properties

[ Molecular Formula ]:
C48H69N15O14S2

[ Molecular Weight ]:
1144.284

[ Exact Mass ]:
1143.458984

Related Compounds