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Asparanin A

Names

[ CAS No. ]:
84633-33-0

[ Name ]:
Asparanin A

[Synonym ]:
(25S)-5β-spirostan-3β-ol-3-O-β-D-glucopyranosyl-(1,2)-β-D-glucopyranoside
asparanin A
3-O-[β-D-glucopyranosyl(1->2)-β-D-glucopyranosyl]-(25S)-5β-spirostan-3β-ol
(25S)-5β-spirostan-3β-ol-3-O-β-D-glucopyranosyl(1->2)-β-D-glucopyranoside
3-O-β-D-glucopyranosyl-(1->2)-β-D-glucopyranosyl-5β(25S)-spirostan-3β-ol
25(S)-schidigera-saponin D5

Biological Activity

[Description]:

Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Zhang F, et al. Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways. J Agric Food Chem. 2020 Jan 8;68(1):213-224..  

Chemical & Physical Properties

[ Molecular Formula ]:
C39H64O13

[ Molecular Weight ]:
740.91800

[ Exact Mass ]:
740.43500

[ PSA ]:
196.99000

[ LogP ]:
1.44220

Precursor & DownStream

Precursor

DownStream

Related Compounds