(+/-)-CIS-3-METHYL-2-PIPERIDINECARBOXYLICACID

Names

[ Name ]:
(+/-)-CIS-3-METHYL-2-PIPERIDINECARBOXYLICACID

[Synonym ]:
tubulozole-C hydrochloride
cis-tubulozole
CIS-TUBULOZOLE HYDROCHLORIDE
TUBULOZOLE-C
TubulozolecHCl
tubulazole
TUBULOZOLE

Biological Activity

[Description]:

Tubulozole is an orally active synthetic microtubule inhibitor. Tubulozole can be used for the research of tumor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vivo]

Tubulozole (oral; 160 mg/kg) 在体内具有抗微管和抗肿瘤作用[1]。 Animal Model: Male CDFi (DBA/Px C3H) hybrids (18-22 g)[1]. Dosage: 160 mg/kg Administration: Oral gavage Result: Had anti-microtubular and anti-tumor effect.

[References]

[1]. Distelmans W, et al. Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989;25(10):1499-1504.

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
646.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₃Cl₂N₃O₄S

[ Molecular Weight ]:
508.42

[ Flash Point ]:
344.9ºC

[ Exact Mass ]:
543.05500

[ PSA ]:
99.91000

[ LogP ]:
6.69400

[ Index of Refraction ]:
1.64

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EZ4208000

CHEMICAL NAME :: Carbamic acid, (4-(((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethy l)-1,3-dioxolan-4-yl) methyl)thio)phenyl)-, ethyl ester, cis-(+-)-

CAS REGISTRY NUMBER :: 84697-22-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H23-Cl2-N3-O4-S

MOLECULAR WEIGHT :: 508.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 244,95,1990