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Gefitinib N-oxide

Names

[ CAS No. ]:
847949-51-3

[ Name ]:
Gefitinib N-oxide

[Synonym ]:
Gefitinib Morpholine N-oxide
Gefitinib N-Oxide
gefitinib N-oxide
Gefitinib Impurity 13

Biological Activity

[Description]:

Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]


[References]

[1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

[2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H24ClFN4O4

[ Molecular Weight ]:
462.90200

[ Exact Mass ]:
462.14700

[ PSA ]:
94.93000

[ LogP ]:
4.32000

Related Compounds