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EX-527 (S-enantiomer)

Names

[ CAS No. ]:
848193-68-0

[ Name ]:
EX-527 (S-enantiomer)

[Synonym ]:
(S)-selisistat
OCZ
S1541_Selleck
(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
cc-651
1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)-
EX527
EX-527 S-enantiomer
EX-527 (S-enantiomer)

Biological Activity

[Description]:

Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.

[Related Catalog]:

Research Areas >> Cancer

[Target]

SIRT1:123 nM (IC50)


[References]

[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.


[Related Small Molecules]

Selisistat (EX 527) | Nicotinamide | SRT1720 HCl | Sirtinol | 3-TYP | SRT 2104 | Fisetin | OSS_128167 | Thiomyristoyl | Cambinol | Tenovin-1 | CAY10602 | AK-7 | Inauhzin | Tenovin 6 Hydrochloride

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
531.7±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H13ClN2O

[ Molecular Weight ]:
248.708

[ Flash Point ]:
275.4±26.8 °C

[ Exact Mass ]:
248.071640

[ PSA ]:
59.87000

[ LogP ]:
2.22

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds