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Tos-PEG5-C2-Boc

Names

[ CAS No. ]:
850090-10-7

[ Name ]:
Tos-PEG5-C2-Boc

[Synonym ]:
MFCD22683305
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15-pentaoxaoctadecan-18-oate

Biological Activity

[Description]:

Tos-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
591.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H40O10S

[ Molecular Weight ]:
520.633

[ Flash Point ]:
311.4±30.1 °C

[ Exact Mass ]:
520.234192

[ LogP ]:
1.37

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.491

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds