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Benzonitrile,4-(4,5-dihydro-1H-imidazol-2-yl)-

Names

[ CAS No. ]:
850786-33-3

[ Name ]:
Benzonitrile,4-(4,5-dihydro-1H-imidazol-2-yl)-

[Synonym ]:
MFCD16877945
4-(4,5-Dihydro-1H-imidazol-2-yl)benzonitrile
Benzonitrile, 4-(4,5-dihydro-1H-imidazol-2-yl)-

Biological Activity

[Description]:

SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule inhibitor of SARS-CoV-2 that targets the main protease (Mpro) of the coronavirus. SARS-CoV-2-IN-59 has a strong interaction with residues on Mpro (Met 165, Gln 166, Met 165, His 41, Gln 189)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

SARS-CoV-2[1]


[References]

[1]. Azimi S, et al. Green and rapid and instrumental one-pot method for the synthesis of imidazolines having potential anti-SARS-CoV-2 main protease activity. Sustain Chem Pharm. 2023 Sep;34:101136.. .  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
327.7±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H9N3

[ Molecular Weight ]:
171.20

[ Flash Point ]:
152.0±28.4 °C

[ Exact Mass ]:
171.079651

[ LogP ]:
0.00

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.642

Related Compounds