m-PEG5-Br

Names

[ CAS No. ]:
854601-80-2

[ Name ]:
m-PEG5-Br

[Synonym ]:
16-Bromo-2,5,8,11,14-pentaoxahexadecane
2,5,8,11,14-Pentaoxahexadecane, 16-bromo-

Biological Activity

[Description]:

m-PEG5-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Jennifer Riggs-Sauthier, et al. Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates. US20120094998A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
342.4±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₃BrO₅

[ Molecular Weight ]:
315.201

[ Flash Point ]:
139.3±23.6 °C

[ Exact Mass ]:
314.072876

[ LogP ]:
-0.54

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.457

m-PEG5-Br

Names

Biological Activity

Chemical & Physical Properties

Related Compounds