Osteocalcin (45-49) (human)

Names

[ Name ]:
Osteocalcin (45-49) (human)

[Synonym ]:
OSTEOCALCIN,Fragment 45-49
Phe-Tyr-Gly-Pro-Val
Osteocalcin Fragment 45-49 human
FYGPV

Biological Activity

[Description]:

Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Bovine bone Gla protein (BGP) (1 nM-10 μM) exerts chemotactic activity of (0.1 and 1 μM) cultured human breast cancer cells (MDA-MB-231 cells), (1 nM-1 μM) human peripheral blood monocytes, and (1-10 μM) rat osteosarcoma cells with osteoblast-like characteristics[1].

[References]

[1]. Mundy GR, et al. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Calcif Tissue Int. 1983;35(2):164-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₉N₅O₇

[ Molecular Weight ]:
581.66000

[ Exact Mass ]:
581.28500

[ PSA ]:
191.16000

[ LogP ]:
2.13300

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport