DL-AP7

Names

[ Name ]:
DL-AP7

[Synonym ]:
2-amino-5-phosphonovaleric acid
acide amino-6 carboxy-6 hexylphosphonique
2-amino-5-phosphopentanoicacid
DL-APV
[3H]-DL-AP7
D-2-amino-5-phosphonovaleric acid
[3H]-DL-AP 5
DL-2-amino-5-phosphonovaleric acid
d-(+/-)-2-amino-5-phosphonopentanoic acid
5-PHOSPHONO-DL-NORVALINE
(-)2-amino-7-phosphonoheptanoic acid
AP-5
APV
2-amino-5-phosphovaleric acid

Biological Activity

[Description]:

DL-AP7 is a competitive NMDA antagonist and an anticonvulsant. DL-AP7 blocks the NMDA-induced convulsions and impairs learning performance in a passive avoidance task in mice[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vivo]

DL-AP7 (ICV) blocks the NMDA-induced convulsions (ED50=0.22 nmol/mouse) and impairs learning performance in a passive avoidance task in mice[1].

[References]

[1]. Chiamulera C, et al. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning. Psychopharmacology (Berl). 1990;102(4):551-552.

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
480.1ºC at 760mmHg

[ Molecular Formula ]:
C₇H₁₆NO₅P

[ Molecular Weight ]:
225.17900

[ Flash Point ]:
244.2ºC

[ Exact Mass ]:
225.07700

[ PSA ]:
130.66000

[ LogP ]:
0.83670

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ1927500

CHEMICAL NAME :: Heptanoic acid, 2-amino-7-phosphono-

CAS REGISTRY NUMBER :: 85797-13-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H16-N-O5-P

MOLECULAR WEIGHT :: 225.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,575,1985

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
MJ1927500

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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