DNP-PEG4-NHS ester

Names

[ CAS No. ]:
858126-78-0

[ Name ]:
DNP-PEG4-NHS ester

[Synonym ]:
dnp-nh-peg(4)-nhs 1-(2,4-dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester

Biological Activity

[Description]:

DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈N₄O₁₂

[ Molecular Weight ]:
528.46700

[ Exact Mass ]:
528.17000

[ PSA ]:
204.27000

[ LogP ]:
2.03590

DNP-PEG4-NHS ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds