2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE

Names

[ CAS No. ]:
85951-65-1

[ Name ]:
2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE

[Synonym ]:
ETONITAZENYL ISOTHIOCYANATE
BIT
Etonitazenyl isothicyanate
Bit alkylating agent
Tocris-0516

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
595ºC at 760 mmHg

[ Melting Point ]:
64-66ºC

[ Molecular Formula ]:
C₂₃H₂₈N₄OS

[ Molecular Weight ]:
408.56000

[ Flash Point ]:
313.6ºC

[ Exact Mass ]:
408.19800

[ PSA ]:
74.74000

[ LogP ]:
5.10190

[ Index of Refraction ]:
1.598

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Nat. Genet. 47 , 1030-7, (2015)

Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2A (MLL)-rearran...

The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.

Stem Cells 33 , 2268-79, (2015)

Hematopoietic stem/progenitor cells (HSPCs) are regulated through numerous molecular mechanisms that have not been interconnected. The transcription factor stem cell leukemia/T-cell acute leukemia 1 (...

Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells.

J. Virol. 89 , 6536-50, (2015)

Endothelial cells (ECs) are a critical target of viruses, and infection of the endothelium represents a defining point in viral pathogenesis. Human cytomegalovirus (HCMV), the prototypical betaherpesv...