1-(3-methyl-2-nitro-phenoxy)-3-(tert-butylamino)propan-2-ol
Names
[ CAS No. ]:
86166-58-7
[ Name ]:
1-(3-methyl-2-nitro-phenoxy)-3-(tert-butylamino)propan-2-ol
[Synonym ]:
dl-zami-1305
Chemical & Physical Properties
[ Molecular Formula ]:
C14H22N2O4
[ Molecular Weight ]:
282.33500
[ Exact Mass ]:
282.15800
[ PSA ]:
87.31000
[ LogP ]:
2.94510
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UA8470000
- CHEMICAL NAME :
- 2-Propanol, 1-(tert-butylamino)-3-(3-methyl-2-nitrophenoxy)-, DL-
- CAS REGISTRY NUMBER :
- 86166-58-7
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C14-H22-N2-O4
- MOLECULAR WEIGHT :
- 282.38
- WISWESSER LINE NOTATION :
- WNR B1 FO1YQ1MX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 76243 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9 gm/kg/26W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 gm/kg/26W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
- TYPE OF TEST :
- Morphological transformation
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 13,18,1985 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,395,1986