Dodecylphosphocholine-d25

Names

[ CAS No. ]:
861924-55-2

[ Name ]:
Dodecylphosphocholine-d25

[Synonym ]:
Ethanaminium, 2-[[(dodecyl-d25-oxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
Dodecyl-d25-phosphocholine

Biological Activity

[Description]:

Dodecylphosphocholine-d25 is the deuterium labeled Dodecylphosphocholine[1]. Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins[2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. de Haas GH, Dijkman R, Ransac S, Verger R. Competitive inhibition of lipolytic enzymes. IV. Structural details of acylamino phospholipid analogues important for the potent inhibitory effects on pancreatic phospholipase A2. Biochim Biophys Acta. 1990;1046(3):249-257.  

[3]. François Dehez, et al. Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity. Biophys J. 2017 Dec 5113(11):2311-2315.  

[4]. Sarah D Cady, et al. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc. 2011 Mar 30133(12):4274-84.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H38NO4P

[ Molecular Weight ]:
351.46200

[ Exact Mass ]:
351.25400

[ PSA ]:
68.40000

[ LogP ]:
5.18530

Related Compounds