NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone

Names

[ CAS No. ]:
86270-92-0

[ Name ]:
NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone

[Synonym ]:
NNK-d3

Biological Activity

[Description]:

NNK-d3 is the deuterium labeled NNK (HY-126477)[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 NNK (100 pM；0-60 分钟) 刺激 PKCα 和 MAPKs ERK1/2 的激活，直接诱导 c-Myc 磷酸化[2]。 NNK (100 pM；96 小时) 增强 WT 细胞增殖，但不影响表达 AA 的 c-Myc 突变体[2]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Jin Z, et al. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279(38):40209-40219.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
423.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₀D₃N₃O₂

[ Molecular Weight ]:
210.24800

[ Flash Point ]:
210.2ºC

[ Exact Mass ]:
210.12000

[ PSA ]:
62.63000

[ LogP ]:
1.65770

[ Index of Refraction ]:
1.557

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317

[ Precautionary Statements ]:
P280-P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
UN 2811 6.1 / PGIII