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HMB-Val-Ser-Leu-VE

Names

[ CAS No. ]:
862891-04-1

[ Name ]:
HMB-Val-Ser-Leu-VE

[Synonym ]:
N-(3-Hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxo-2-hepten-4-yl]-L-serinamide
N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxohept-2-en-4-yl]-L-serinamide
L-Serinamide, N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]-

Biological Activity

[Description]:

HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Others

[Target]

IC50: prototype vinyl ester[1]


[References]

[1]. Anna Baldisserotto, et al. C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors. Eur J Med Chem. 2008 Jul;43(7):1403-11.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
754.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H39N3O7

[ Molecular Weight ]:
505.60

[ Flash Point ]:
409.8±32.9 °C

[ Exact Mass ]:
505.278809

[ PSA ]:
154.06000

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.539

Related Compounds