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10-hydroxycanthin-6-one

Names

[ CAS No. ]:
86293-41-6

[ Name ]:
10-hydroxycanthin-6-one

[Synonym ]:
10-Hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one,10-hydroxy
ervine
CHEBI:66064

Biological Activity

[Description]:

10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

10-Hydroxycanthin-6-one shows antibacterial activity with a MIC of 15.62 µg/mL for B. cereus[1].

[References]

[1]. N Fukamiya, et al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53(2):140-3.

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
410.1ºC at 760mmHg

[ Molecular Formula ]:
C14H8N2O2

[ Molecular Weight ]:
236.22600

[ Flash Point ]:
201.8ºC

[ Exact Mass ]:
236.05900

[ PSA ]:
54.60000

[ LogP ]:
2.14430

[ Index of Refraction ]:
1.795

[ Water Solubility ]:
Very slightly soluble (0.61 g/L) (25 ºC)

Related Compounds