Glyco-Obeticholic acid

Names

[ Name ]:
Glyco-Obeticholic acid

Biological Activity

[Description]:

Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Research Areas >> Inflammation/Immunology

[In Vitro]

Obeticholic acid is conjugated with glycine in the liver to form glycol-obeticholic acid, which is secreted into bile. Microorganisms in the ileum and colon can deconjugate glyco-obeticholic acid, converting it into the parent drug, which may then be reabsorbed or excreted in faeces[1].

[References]

[1]. Markham A, et al. Obeticholic Acid: First Global Approval. Drugs. 2016 Aug;76(12):1221-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₄₇NO₅

[ Molecular Weight ]:
477.68

Glyco-Obeticholic acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds