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Methoxy-X04

Names

[ CAS No. ]:
863918-78-9

[ Name ]:
Methoxy-X04

[Synonym ]:
m-methoxy-trans-β-nitrostyrene
1,4-bis (4''-hydroxystyrl)-2-methoxybenzene
(E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene

Biological Activity

[Description]:

Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques.

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Klunk WE, Bacskai BJ, Mathis CA, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002;61(9):797-805. doi:10.1093/jnen/61.9.797

[2]. Bisht K, El Hajj H, Savage JC, Sánchez MG, Tremblay MÈ. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016;(112):54060. Published 2016 Jun 1.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20O3

[ Molecular Weight ]:
344.40300

[ Exact Mass ]:
344.14100

[ PSA ]:
49.69000

[ LogP ]:
5.44720

Related Compounds