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TP0427736 HCl

Names

[ CAS No. ]:
864374-00-5

[ Name ]:
TP0427736 HCl

[Synonym ]:
6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-

Biological Activity

[Description]:

TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
634.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H10N4S2

[ Molecular Weight ]:
298.39

[ Flash Point ]:
333.8±24.7 °C

[ Exact Mass ]:
298.034698

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.740

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
DMSO ：≥50mg/mL

Safety Information

[ Hazard Codes ]:
N

Related Compounds