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TCA-1

Names

[ CAS No. ]:
864941-32-2

[ Name ]:
TCA-1

[Synonym ]:
Carbamic acid, N-[[2-[(2-benzothiazolylcarbonyl)amino]-3-thienyl]carbonyl]-, ethyl ester
Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate
MFCD04430653
Ethyl ({2-[(1,3-Benzothiazol-2-Ylcarbonyl)amino]thiophen-3-Yl}carbonyl)carbamate

Biological Activity

[Description]:

A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.

[References]

References 1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C16H13N3O4S2

[ Molecular Weight ]:
375.422

[ Exact Mass ]:
375.034760

[ LogP ]:
4.47

[ Index of Refraction ]:
1.709

Related Compounds