HS-PEG8-CH2CH2COOH

Names

[ CAS No. ]:
866889-02-3

[ Name ]:
HS-PEG8-CH2CH2COOH

[Synonym ]:
AmbotzPEG1120
PEG thiol acid
4,7,10,13,16,19,22,25-Octaoxaheptacosanoicacid,27-mercapto

Biological Activity

[Description]:

Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₃₈O₁₀S

[ Molecular Weight ]:
458.56400

[ Exact Mass ]:
458.21900

[ PSA ]:
149.94000

[ LogP ]:
0.52370

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi