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Rhodiosin

Names

[ CAS No. ]:
86831-54-1

[ Name ]:
Rhodiosin

[Synonym ]:
herbacetin 7-O-(3'-O-β-D-glucopyranosyl-α-L-rhamnopyranoside)
3,5,8-Trihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-deoxy-3-O-β-D-glucopyranosyl-α-L-mannopyranoside
Herbacetin-7-O-glucorhamnoside
4H-1-BENZOPYRAN-4-ONE,7-[(6-DEOXY-3-O-B-D-GLUCOPYRANOSYL-A-L-MANNOPYRANOSYL)OXY]-3,5,8-TRIHYDROXY-2-(4-HYDROXYPHENYL)-
4H-1-Benzopyran-4-one, 7-[(6-deoxy-3-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-3,5,8-trihydroxy-2-(4-hydroxyphenyl)-
Rhodiosin

Biological Activity

[Description]:

Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM[1]. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM[3].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 0.420 μM (cytochrome P450 2D6)[1]；57.50-2.43 μg/mL (AChE)[2]；27.77 μM (DPPH free radical scavenging)[3]


[References]

[1]. Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6.

[2]. Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532.

[3]. Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
994.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H30O16

[ Molecular Weight ]:
610.518

[ Flash Point ]:
329.1±27.8 °C

[ Exact Mass ]:
610.153381

[ PSA ]:
269.43000

[ LogP ]:
-2.25

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.765

Related Compounds