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WAY 213613

Names

[ CAS No. ]:
868359-05-1

[ Name ]:
WAY 213613

[Synonym ]:
way-213,613

Biological Activity

[Description]:

WAY-213613 is a potent, selective human EAAT2 inhibitor (IC50, 85 nM), exhibits 59- and 45-fold selectivity over human EAAT1 and EAAT3. Inhibits glutamate uptake in rat cortical synaptosomes[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2
Research Areas >> Neurological Disease

[Target]

IC50: 85 nM (Human EAAT2), 3.8 μM (Human EAAT3), 5 μM (Human EAAT1)[1]


[In Vitro]

WAY-213613 exhibits IC50s of 5 and 3.8 μM for EAAT1 and EAAT3, respectively[1].

[References]

[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.

Chemical & Physical Properties

[ Density]:
1.665g/cm3

[ Boiling Point ]:
565.634ºC at 760 mmHg

[ Molecular Formula ]:
C16H13BrF2N2O4

[ Molecular Weight ]:
415.19

[ Flash Point ]:
295.885ºC

[ Exact Mass ]:
414.00300

[ PSA ]:
101.65000

[ LogP ]:
4.03340

[ Index of Refraction ]:
1.632

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds