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TLQP-21 (mouse, rat) trifluoroacetate salt

Names

[ CAS No. ]:
869988-94-3

[ Name ]:
TLQP-21 (mouse, rat) trifluoroacetate salt

[Synonym ]:
H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH

Biological Activity

[Description]:

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Neurological Disease

[In Vitro]

TLQP-21 is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of the corresponding contraction promoted by acetylcholine[1][2].

[References]

[1]. Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130.

[2]. Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753.

Chemical & Physical Properties

[ Molecular Formula ]:
C107H170N40O26

[ Molecular Weight ]:
2432.75000

[ Exact Mass ]:
2431.32000

[ PSA ]:
1047.58000

[ LogP ]:
0.26540

Related Compounds