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Ms-PEG4-t-butyl ester

Names

[ CAS No. ]:
870487-48-2

[ Name ]:
Ms-PEG4-t-butyl ester

[Synonym ]:
MFCD20926382
2-Methyl-2-propanyl 3,6,9,12,15-pentaoxa-2-thiaoctadecan-18-oate 2,2-dioxide
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Ms-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
499.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H32O9S

[ Molecular Weight ]:
400.485

[ Flash Point ]:
256.1±27.3 °C

[ Exact Mass ]:
400.176697

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.460

Related Compounds