m-PEG6-Boc

Names

[ Name ]:
m-PEG6-Boc

[Synonym ]:
2-Methyl-2-propanyl 2,5,8,11,14,17,20-heptaoxatricosan-23-oate
MFCD28950751
2,5,8,11,14,17,20-Heptaoxatricosan-23-oic acid, 1,1-dimethylethyl ester

Biological Activity

[Description]:

m-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
467.7±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₄₀O₉

[ Molecular Weight ]:
424.526

[ Flash Point ]:
197.2±27.4 °C

[ Exact Mass ]:
424.267242

[ LogP ]:
-0.73

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.447

m-PEG6-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds