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Tiospirone

Names

[ CAS No. ]:
87691-91-6

[ Name ]:
Tiospirone

[Synonym ]:
Tiospirona [Spanish]
tiaspirone
Tiospirone [INN]
Tiospironum [Latin]
[14C]-Tiospirone
Tiospironum
Tiospirona
8-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione
8-Azaspiro(4,5)decane-7,9-dione,8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)
TIOSPIRONE

Biological Activity

[Description]:

Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8.  

[2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81.  

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
600.9ºC at 760 mmHg

[ Molecular Formula ]:
C24H32N4O2S

[ Molecular Weight ]:
440.60100

[ Flash Point ]:
317.2ºC

[ Exact Mass ]:
440.22500

[ PSA ]:
84.99000

[ LogP ]:
3.84870

[ Index of Refraction ]:
1.652

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds