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Eupalinolide B

Names

[ CAS No. ]:
877822-40-7

[ Name ]:
Eupalinolide B

[Synonym ]:
2-Butenoic acid, 4-hydroxy-2-methyl-, (3aR,4R,6E,9S,10Z,11aR)-9-(acetyloxy)-6-[(acetyloxy)methyl]-2,3,3a,4,5,8,9,11a-octahydro-10-methyl-3-methylene-2-oxocyclodeca[b]furan-4-yl ester, (2E)-
Eupalinolide B
Eupalinolide A
(3aR,4R,6E,9S,10Z,11aR)-9-Acetoxy-6-(acetoxymethyl)-10-methyl-3-methylene-2-oxo-2,3,3a,4,5,8,9,11a-octahydrocyclodeca[b]furan-4-yl (2E)-4-hydroxy-2-methyl-2-butenoate
Eupalinolide G
EupalinolideB
Eupalinolide-B

Biological Activity

[Description]:

Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSF1


[References]

[1]. Yamashita Y, et al. Purification and characterization of HSP-inducers from Eupatorium lindleyanum. Biochem Pharmacol. 2012;83(7):909-922.

Chemical & Physical Properties

[ Density]:
1.24±0.1 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
618.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H30O9

[ Molecular Weight ]:
462.490

[ Flash Point ]:
205.4±25.0 °C

[ Exact Mass ]:
462.188995

[ PSA ]:
125.43000

[ LogP ]:
2.50

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

Related Compounds