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3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine

Names

[ CAS No. ]:
87827-02-9

[ Name ]:
3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine

[Synonym ]:
2-(1-Azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol
Benzenemethanol, α-((1-azabicyclo(2.2.2)oct-3-yloxy)methyl)-α-cyclopentyl-
UNII:353CX8CSHD
Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-
m 8218
3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine

Biological Activity

[Description]:

Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Inflammation/Immunology

[Target]

NF-κB


[References]

[1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.

[2]. Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
461.0±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H29NO2

[ Molecular Weight ]:
315.450

[ Flash Point ]:
232.6±25.9 °C

[ Exact Mass ]:
315.219818

[ PSA ]:
32.70000

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.588

Related Compounds