L-Leucine-d3

Names

[ Name ]:
L-Leucine-d3

[Synonym ]:
(S)-Leucine-d3
L-Leucine-5,5,5-d3
L-Leucine-5,5,5-d
L-(5,5,5-H)Leucine
MFCD00144628
L-|A-Aminoisocaproic Acid-d3
L-Leucine-d3
(S)-2-Amino-4-methylvaleric Acid-d3
L-2-Amino-4-methylpentanoic Acid-d3

Biological Activity

[Description]:

L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg

[ Melting Point ]:
>300ºC(lit.)

[ Molecular Formula ]:
C₆H₁₀D₃NO₂

[ Molecular Weight ]:
134.191

[ Flash Point ]:
90.3±22.6 °C

[ Exact Mass ]:
134.113464

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport