Aurora Kinase Inhibitor 3

Names

[ Name ]:
Aurora Kinase Inhibitor 3

[Synonym ]:
Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide
Anilinopyrimidine1
2np8
Aurora Kinase Inhibitor III
N-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide

Biological Activity

[Description]:

Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase

Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

Research Areas >> Others

[Target]

Aurora A:42 nM (IC50)

[References]

[1]. Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈F₃N₅O

[ Molecular Weight ]:
413.39600

[ Exact Mass ]:
413.14600

[ PSA ]:
85.66000

[ LogP ]:
5.47550

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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