INF 4E

Names

[ Name ]:
INF 4E

[Synonym ]:
2-[hydroxy(2-chlorophenyl)methyl]acrylic acid ethyl ester
2-[(2-Chloro-phenyl)-hydroxy-methyl]-acrylic acid ethyl ester

Biological Activity

[Description]:

INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

[In Vitro]

INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent mannersup>[3].

[In Vivo]

INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure[1]. INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way[1].

[References]

[1]. Shi Y, et al. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021 Mar;92:107358.

[2]. Mezzaroma E,et al. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021 Feb 12;26(4):976.

[3]. occo M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₃ClO₃

[ Molecular Weight ]:
240.68300

[ Exact Mass ]:
240.05500

[ PSA ]:
46.53000

[ LogP ]:
2.49270

[ Storage condition ]:
-20°C

INF 4E

Names

Biological Activity

Chemical & Physical Properties

Related Compounds