<Suppliers Price>

Foxy 5 TFA

Names

[ CAS No. ]:
881188-51-8

[ Name ]:
Foxy 5 TFA

[Synonym ]:
FOXY-5
N-Formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-L-leucine
CBZ9UL0ARB
L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-

Biological Activity

[Description]:

Foxy-5 is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 is a WNT5A agonist and effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

WNT5A[1]


[In Vivo]

Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1]. Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer[2].

[References]

[1]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418.

[2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1244.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H42N6O12S2

[ Molecular Weight ]:
694.775

[ Flash Point ]:
706.2±34.3 °C

[ Exact Mass ]:
694.230225

[ LogP ]:
0.62

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.562

Related Compounds