KPT-6566

Names

[ Name ]:
KPT-6566

Biological Activity

[Description]:

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 640 nM (PIN1 PPIase)[1] Ki: 625.2 nM (PIN1 PPIase)[1]

[References]

[1]. Campaner E, et al. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. Nat Commun. 2017 Jun 9;8:15772.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁NO₅S₂

[ Molecular Weight ]:
443.54

KPT-6566

Names

Biological Activity

Chemical & Physical Properties

Related Compounds