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Succinylacetone

Names

[ CAS No. ]:
881835-86-5

[ Name ]:
Succinylacetone

[Synonym ]:
Succinylacetone-13C5
4,6-Dioxoheptanoic-3,4,5,6,7-13C5 Acid
4,6-Dioxoheptanoic Acid-13C5

Biological Activity

[Description]:

4,6-Dioxoheptanoic acid-13C5 is the 13C labeled 4,6-Dioxoheptanoic acid[1]. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.  

Chemical & Physical Properties

[ Molecular Formula ]:
C7H10O4

[ Molecular Weight ]:
163.11500

[ Exact Mass ]:
163.07500

[ PSA ]:
71.44000

[ LogP ]:
0.39940

Related Compounds