iMDK

Names

[ CAS No. ]:
881970-80-5

[ Name ]:
iMDK

[Synonym ]:
3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-
MFCD07528492

Biological Activity

[Description]:

iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF; inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis; significantly inhibits tumor growth in a xenograft mouse model in vivo.

[References]

References 1. Hao H, et al. PLoS One. 2013 Aug 16;8(8):e71093. 2. Ishida N, et al. Exp Cell Res. 2015 Jul 15;335(2):197-206. 3. Masui M, et al. Anticancer Res. 2016 Jun;36(6):2775-81. View Related Products by Target Midkine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₁₃FN₂O₂S

[ Molecular Weight ]:
376.404

[ Exact Mass ]:
376.068176

[ LogP ]:
6.14

[ Index of Refraction ]:
1.711

Safety Information

[ Hazard Codes ]:
Xi