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α-Conotoxin MI trifluoroacetate salt

Names

[ CAS No. ]:
88217-10-1

[ Name ]:
α-Conotoxin MI trifluoroacetate salt

[Synonym ]:
alpha-conotoxin MI
α-Conotoxin MI trifluoroacetate salt

Biological Activity

[Description]:

α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[Target]

mAChR[2]; α1β1γδ nAChR[1]


[In Vitro]

α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C58H88N22O17S4

[ Molecular Weight ]:
1493.72000

[ Exact Mass ]:
1492.56000

[ PSA ]:
739.97000

Related Compounds