A2793

Names

[ CAS No. ]:
88349-90-0

[ Name ]:
A2793

[Synonym ]:
MFCD04275530

Biological Activity

[Description]:

A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5)[1]. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1[1].

[References]

[1]. Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.

Chemical & Physical Properties

[ Density]:
1.291±0.06 g/cm3

[ Boiling Point ]:
393.4±27.0 °C

[ Molecular Formula ]:
C₁₃H₁₂ClNO₃

[ Molecular Weight ]:
265.69200

[ Exact Mass ]:
265.05100

[ PSA ]:
48.42000

[ LogP ]:
2.83010

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn