MLS1082

Names

[ Name ]:
MLS1082

[Synonym ]:
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclohexyl-10-methyl-3-phenyl-
2-Cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione

Biological Activity

[Description]:

MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies.

[References]

References 1. Luderman KD, et al. Mol Pharmacol. 2018 Aug 1. pii: mol.118.113175. View Related Products by Target Dopamine Receptor

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
520.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₃N₃O₂

[ Molecular Weight ]:
385.458

[ Flash Point ]:
268.4±32.9 °C

[ Exact Mass ]:
385.179016

[ LogP ]:
2.78

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.688