<Suppliers Price>

(E)-FeCP-oxindole

Names

[ CAS No. ]:
884338-18-5

[ Name ]:
(E)-FeCP-oxindole

[Synonym ]:
(E)-FeCP-oxindole
SB 258719 hydrochloride

Biological Activity

[Description]:

(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H15FeNO

[ Molecular Weight ]:
329.17

[ Exact Mass ]:
319.98000

[ PSA ]:
29.10000

[ LogP ]:
3.20130

Related Compounds