HJC 0350
Names
Biological Activity
[Description]:
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM.
[Related Catalog]:
[Target]
IC50: 0.3 µM (EPAC2)[1]
[In Vitro]
HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1].
[References]
[Related Small Molecules]
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Mitoquinone mesylate
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GSK2795039
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JC-1
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BAPTA-AM
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Crotaline
Chemical & Physical Properties
[ Molecular Formula ]:
C15H19NO2S
[ Molecular Weight ]:
277.38200
[ Exact Mass ]:
277.11400
[ PSA ]:
47.45000
[ LogP ]:
4.34790
[ Storage condition ]:
-20℃
Safety Information
[ Hazard Codes ]:
N
[ RIDADR ]:
NONH for all modes of transport