Acid-PEG2-ethyl propionate

Names

[ CAS No. ]:
886362-90-9

[ Name ]:
Acid-PEG2-ethyl propionate

[Synonym ]:
3-[2-(3-ethoxy-3-oxopropoxy)ethoxy]propanoic acid

Biological Activity

[Description]:

Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.145g/cm3

[ Boiling Point ]:
370.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₈O₆

[ Molecular Weight ]:
234.24600

[ Flash Point ]:
139.5ºC

[ Exact Mass ]:
234.11000

[ PSA ]:
82.06000

[ LogP ]:
0.44750

[ Index of Refraction ]:
1.452

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2918990090

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%