MK-0674

Names

[ Name ]:
MK-0674

Biological Activity

[Description]:

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. MK-0674 exhibits long half-lives in rats, rabbits and rhesus monkeys[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

IC50: 0.4 nM (Cathepsin K)[1]

[In Vitro]

MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].

[References]

[1]. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₇F₆N₃O₂

[ Molecular Weight ]:
527.50200

[ Exact Mass ]:
527.20100

[ PSA ]:
85.15000

[ LogP ]:
6.30608

MK-0674

Names

Biological Activity

Chemical & Physical Properties

Related Compounds