<Suppliers Price>

SARS-CoV-IN-1

Names

[ CAS No. ]:
888958-25-6

[ Name ]:
SARS-CoV-IN-1

Biological Activity

[Description]:

SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

EC50: 4.9 μM (SARS-CoV, in Vero cells)[1] IC50: 15.4 nM (3D7 P. falciparum), 133.2 nM (W2 P. falciparum)[1] IC90: 25.7 nM (3D7 P. falciparum), 459.1 nM (W2 P. falciparum)[1]


[In Vitro]

SARS-CoV-IN-1 (Compound 2) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].

[References]

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H16ClFeN3O

[ Molecular Weight ]:
441.69

Related Compounds