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SARS-CoV-IN-3

Names

[ CAS No. ]:
888958-27-8

[ Name ]:
SARS-CoV-IN-3

Biological Activity

[Description]:

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

EC50: 3.6 μM (SARS-CoV, in Vero cells)[1] IC50: 11.7 nM (3D7 P. falciparum), 20.4 nM (W2 P. falciparum)[1] IC90: 29.19 nM (3D7 P. falciparum), 56 nM (W2 P. falciparum)[1]


[In Vitro]

SARS-CoV-IN-3 (Compound 4) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].

[References]

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20ClFeN3O

[ Molecular Weight ]:
469.74

Related Compounds