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Mogroside III-A2

Names

[ CAS No. ]:
88901-43-3

[ Name ]:
Mogroside III-A2

[Synonym ]:
β-D-glucopyranoside, (1R,4R)-4-[(3β,9β,10α,11α,17β)-3-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-11-hydroxy-4,4,9,14-tetramethylestr-5-en-17-yl]-1-(1-hydroxy-1-methylethyl)pentyl
β-D-Glucopyranoside, (1R,4R)-4-[(3β,9β,10α,11α,17β)-3-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-11-hydroxy-4,4,9,14-tetramethylestr-5-en-17-yl]-1-(1-hydroxy-1-methylet hyl)pentyl
(1S,4R,9β,11α,24R)-1-{[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy}-11,25-dihydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-en-24-yl β-D-glucopyranoside

Biological Activity

[Description]:

Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection

[Target]

Epstein-Barr virus[1]


[In Vitro]

Mogroside III A2 inhibits the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with IC50 of 352 mol ratio/32 pmol TPA[1]. Mogroside III A2 shows weak inhibitory effects on activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1)[1].

[References]

[1]. Akihisa T, et, al. Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2007 May;70(5):783-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1048.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C48H82O19

[ Molecular Weight ]:
963.153

[ Flash Point ]:
587.8±34.3 °C

[ Exact Mass ]:
962.545044

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds