3,5-DIHYDROXY-2-NAPHTHOIC ACID

Names

[ CAS No. ]:
89-35-0

[ Name ]:
3,5-DIHYDROXY-2-NAPHTHOIC ACID

[Synonym ]:
3,5-DIHYDROXY-2-NAPHTHOIC ACID
3,5-dihydroxynaphthalene-2-carboxylic acid
EINECS 201-900-8
2-Naphthalenecarboxylic acid, 3,5-dihydroxy-
MFCD00003982

Biological Activity

[Description]:

3,5-Dihydroxy-2-naphthoic acid is a Naphthoic acid derivative. Naphthoic acid is a NMDA receptor allosteric modulator[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Monaghan DT, et al. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 2012 Sep;61(4):581-92.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
442.2±35.0 °C at 760 mmHg

[ Melting Point ]:
275-280 °C(lit.)

[ Molecular Formula ]:
C₁₁H₈O₄

[ Molecular Weight ]:
204.18

[ Flash Point ]:
235.3±22.4 °C

[ Exact Mass ]:
204.042252

[ PSA ]:
77.76000

[ LogP ]:
2.52

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.762

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918290000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

J. Biol. Chem. 283(21) , 14694-702, (2008)

Neocarzinostatin, a clinical anticancer drug, is the archetypal member of the chromoprotein family of enediyne antitumor antibiotics that are composed of a nonprotein chromophore and an apoprotein. Th...