Boc-amido-PEG9-amine

Names

[ Name ]:
Boc-amido-PEG9-amine

[Synonym ]:
O-(2-Aminoethyl)-O inverted exclamation marka-[2-(Boc-amino)ethyl]octaethylene glycol
O-(2-aminoethyl)-O'-[2-(Boc-amino)ethyl]octaethylene glycol
Boc-PEG-amine (n=9)
(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)ethoxy]ethoxy}ethyl)carbamic acid tert-butyl ester

Biological Activity

[Description]:

Boc-amido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.082g/cm3

[ Boiling Point ]:
609.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₅₂N₂O₁₁

[ Molecular Weight ]:
556.68700

[ Flash Point ]:
322.6ºC

[ Exact Mass ]:
556.35700

[ PSA ]:
150.91000

[ LogP ]:
1.52390

[ Index of Refraction ]:
1.465

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport