Saracatinib difumarate

Names

[ CAS No. ]:
893428-72-3

[ Name ]:
Saracatinib difumarate

[Synonym ]:
Saracatinib difumarate
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine (2E)-2-butenedioate (1:2)
UNII-8R1DYT4EAW
AZD-0530 difumarate
4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

Biological Activity

[Description]:

Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

[Target]

IC50: 2.7 nM (Src), 30 nM (v-Abl), 66 nM (EGFR), 200 nM (c-Kit)[1]


[References]

[1]. Green TP, et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol Oncol, 2009, 3(3), 248-261.  

Chemical & Physical Properties

[ Molecular Formula ]:
C35H40ClN5O13

[ Molecular Weight ]:
774.171

[ Exact Mass ]:
773.231140

[ PSA ]:
239.64000

[ LogP ]:
3.31190

Related Compounds